Effectiveness of the Clindamycin as a prophylactic antibiotic in the third molar surgery
The use of prophylactic antibiotic therapy in healthy patients undergoing oral surgery is a constant, despite this being a controversial issue. The American Heart Association (AHA) states as the first choice prophylactic antibiotic penicillin as a percentage of the population is allergic to this antibiotic, in this case determined that Clindamycin is a drug indicated for this purpose. The aim of this study was to determine the effectiveness of clindamycin as antibiotic prophylaxis in third molar surgery. To this end were randomly selected 90 patients with indication for surgery of the third molars, from the dental office Graduate School of Dentistry, VCU who were assigned to drug treatment setting 6 groups of 15 patients: group A received 2 capsules of 300 milligrams of clindamycin to be administered one hour before surgery. The A1 group received 4 capsules of 500 milligrams of amoxicillin (Trimoxal) for administration one hour before surgery. Group B received 12 capsules of 300 milligrams of clindamycin to be administered at a rate of 1 capsule every 6 hours orally, starting one hour before surgery until three days after third molar surgery. The B1 group received 21 capsules of 500 milligrams of amoxicillin (Trimoxal) to be administered at a rate of 1 tablet every 8 hours orally for 7 days after third molar surgery. Groups C and C1 did not receive antibiotics but Placebo. In addition, all therapy groups received anti-inflammatory analgesic and 600 milligrams of ibuprofen (Motrin) every 6 hours, orally, for three days. Several controls were performed to assess the presence of pain, exudate, odor and bad taste as symptoms and signs of infection. The evaluation results showed that clindamycin is as effective as amoxicillin in any of the proposed therapeutic regimens. According to our results is advisable to indicate the outline of a single dose of clindamycin before surgery in patients allergic to penicillin.
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